作者:2020-09-01浏览次数:5815

蒋爱芹-j9集团

研究生导师简介

姓名

蒋爱芹

研究方向

肿瘤靶向治疗研究

j9集团的联系方式

email

025-83594757

学术兼职:

中国细胞生物学会会员


个人简介


1.工作简历

2009-至今     南京大学医学院  讲师、副教授

2005-2009年     南京大学分子医学研究所 讲师


2.科研情况简介

主要从事肿瘤的治疗研究。以第一作者或通讯作者身份在sci收录杂志上发表论文计20篇。主持国家自然科学基金1项,教育部课题1项,南京大学中央高校项目多项和双创项目1项。


3.研究兴趣:

(1) 天然产物或化学合成来源的抗肿瘤靶向药物的研究

(2)   三阴性乳腺癌药物的筛选与作用机制研究


代表性论文[近年通讯作者和第一作者]

1kai wang, ya-xi ye, cheng-yan jiang, meng-ya guo, xiang-yang zhang, ai-qin jiang, yu-shun yang, qing-cai jiao, hai-liang zhu. design and synthesis of a novel "turn-on" fluorescent probe based on benzofuran-3(2h)-one for detection of hydrazine in water samples and biological systems. dyes and pigments, 2021,109587. (通讯作者,if 4.889/q1)

2kai wang, wei wang, xiang-yang zhang, ai-qin jiang, yu-shun yang,

hai-liang zhu. fluorescent probes for the detection of alkaline phosphatase in

biological systems: recent advances and future prospects. trends in analytical chemistry, 2021, 136: 116189. (通讯作者,if 12.296/q1)

3)ya-lin qi, long guo, li-li chen, hua li, yu-shun yang, ai-qin jiang, hai-liang zhu. recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases. coordination chemistry reviews, 2020, 421: 213460. (通讯作者, if 22.315/q1)

4ya-liang zhang, bo-yan li, rong yang, lin-ying xia, a-li fan, yi-chun chu, lin-jian wang, zhong-chang wang, ai-qin jiang, hai-liang zhu. a class of novel tubulin polymerization inhibitors exert effective antitumor activity via mitotic catastrophe. european journal of medicinal chemistry. 2019, 163, 896-910. (通讯作者, if 6.514/q1)

5ya-liang zhang, rong yang, lin-ying xia, ruo-jun man, yi-chun chu, ai-qin jiang, zhong-chang wang, hai-liang zhu. synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents. bioorganic chemistry 2019, 92: 103219. (通讯作者, if 5.275/q3)

6ruo-jun man, ya-liang zhang, ai-qin jiang, hai-liang zhu. a patent review of raf kinase inhibitors (2010–2018), expert opinion on therapeutic patents, 2019, 29:675-688.(通讯作者, if 6.674/q3

7chun xu, mao xia, gang meng, chunyan li, aiqin jiang, jiwu wei. carrier cells for delivery of oncolytic measles virus into tumors determinants of efficient loading. virologica sinica. 2018, 33:234–240.(通讯作者, if 4.327/q4

8ya-juan qin, yu-jinglia, ai-qin jiang, meng-ruyangqi-zhang zhuhong dong, hai-liang zhu. design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors. european journal of medicinal chemistry. 2015, 94: 447-457. (通讯作者, if 6.514/q1

9yu-jia ren, zhong-chang wang, xin zhang, han-yue qiu, peng-fei wang, ai-qin jiang, hai-liang zhu. egfr/her-2 inhibitors:synthesis, biological evaluation and analysis of dihydropyridine-containing thiazolinone derivatives. rsc adv. 2015, 5: 21445-21454. (通讯作者, if 3.361/q2

(10) jin-hong liu, zi-fei zhu, jia tang, ai-qin jiang, liu-fang hua, li chen. novel no-releasing derivatives of betulinic acid with antitumor activity. chinese chemical letters, 2015, 26:759–762. (通讯作者, if 6.779/q2

(11) chun yan ligang menglei suai ping chenmao xchun xudecai yu, aiqin jiangji wu weidichloroacetate blocks aerobic glycolytic adaptation toattenuated measles virus and promotes viral replication leadingto enhanced oncolysis in glioblastomaoncotarget20156: 1544-1555. (通讯作者)

(12) aiqin jiangwenbo jinfeng zhaoziyong sunjianning liusplit ssp dnab mini-intein mediated production of recombinant human glucagon-like peptide-1/7-36biotechnology and applied biochemistry201562309-315. (第一作者, if 2.431

承担科研项目[项目负责人]

1、南京大学2021双创科教融合项目 antimycin-1-peg-pcl纳米颗粒制备及抗三阴性乳腺癌活性研究

2南京大学双创基地重点项目(0214 1499 9103)新型抗肿瘤生物医药研发及产业化平台建设

3、南京大学2020年中央高校重点项目培育计划 天然产物来源的药物对三阴性乳腺癌抑制作用的筛选及机制研究

4、国家自然科学青年基金项目(81301943) 自噬调控溶瘤麻疹病毒疫苗株复制及溶瘤的机制研究

5、教育部博士点新教师基金(20120091120023)  sirt6:一个潜在的抑癌基因对肿瘤进行调控的研究

6、中央高校基本科研业务技术创新项目(021414380114) 基于免疫诱导小干扰rna的抗肿瘤新药研发2015/10-2016/10

7、中央高校基本科研业务苗圃项目(021414340243) 自噬调控溶瘤麻疹病毒疫苗株复制及溶瘤的机制研究 2014/01-2014/12

8、中央高校基本科研业务苗圃项目 (020620130633) 自噬调控溶瘤麻疹病毒疫苗株复制及溶瘤的机制研究2013/01-2013/12

9、中央高校基本科研业务自由探索项目(021414340078) intein蛋白介导的重组蛋白药物制备研究




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