研究生导师简介
姓名 | 朱敏生 | 研究方向： | 肠道微生物与平滑肌生理学 |
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j9集团的联系方式 | zhums@nju.edu.cn | ||||
学术兼职： 中国细胞生物学会理事 江苏省发育生物学会监事 | |||||
个人简介 | |||||
1995年毕业于中国科学院上海生物化学研究所，获理学博士学位。1999-2001年间在美国德州大学西南医学中心生理系从事博士后研究，2004年至今在南京大学任教授。长期从事小鼠遗传学、平滑肌收缩生理学与疾病研究。在系统生物学水平，研究阐明了平滑肌收缩钙机制、钙敏机制的分子基础；从平滑肌角度，系统阐明了胃肠动力调节机制、肛门括约肌的自发收缩机制、哮喘高反应性形成机制、肥胖性高血压形成机制等。在此基础上，开展平滑肌相关疾病（如胃肠病、哮喘、血管病、神经退行性病变等）的发病机制研究和转化研究。研究成果分别发表在 gastroenterology（2008、2013）、j clin invest.（2022）、pnas(2015、2022)、j. biol. chem. (2010、2010、2014、2014、2019、2021)、j physiol (2014)、 am j. physiol (2011)、nature med (2012)、 ajrccm (2013)、nature communications(2016)、genome biol (2016)、j allegy clin immunol (2018)、cmgh（2019）等权威杂志上。2016年获国家科技进步二等奖1项（第2）。 | |||||
代表性论文[近5年通讯作者和第一作者] | |||||
1. zhou yw, sun j, wang y, chen cp, tao t, ma m, chen x, zhang xn, yang ly, zhang zl, li yq, jiang zh, qiu tt, wang h, pan y, zhang j, chen hq, wang p, zhu ms. tas2r activation relaxes airway smooth muscle by release of gαt targeting on achr signaling. pnas. 2022 jun 28;119(26):e2121513119. doi: 10.1073/pnas.2121513119.
2. chen x, qiu tt, wang y, xu ly, sun j, jiang zh, zhao w, tao t, zhou yw, wei l, li y, zheng y, zhou gh, chen h, zhang j, feng xb, wang f, li n, zhang xn, jiang j, zhu ms. a shigella sp. variant is causally linked to intractable functional constipation. j clin invest. 2022 may 26:e150097. doi: 10.1172/jci150097.
3. zheng yy, wang y, chen x, wei ls, wang h, tao t, zhou yw, jiang zh, qiu tt, sun zy, sun j, wang p, zhao w, li yq, chen hq, zhu ms, zhang xn. the thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion. j biol chem. 2022 jan;298(1):101516. doi: 10.1016/j.jbc.2021.101516.
4. li y, zhou y, wang p, tao t, wei l, wang y, wang w, zheng y, jiang z, qiu t, zhao w, sun j, chen x, zhang xn, zhu ms. limk2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle. j genet genomics. 2021 jun 20;48(6):452-462. doi: 10.1016/j.jgg.2021.04.014.
5. li-sha wei, yan-yan zheng, jie sun, pei wang, tao tao, yeqiong li, xin chen, yongjuan sang, danyang chong, wei zhao, yuwei zhou, ye wang, zhihui jiang, tiantian qiu, chao-jun li*, min-sheng zhu*, xuena zhang* ggpp depletion initiates metaflammation through disequilibrating cyb5r3-dependent eicosanoid metabolism. j biol chem 2020 in press.
6. chen x, yun-qian gao, yan-yan zheng, wei wang, pei wang, juan liang, wei zhao, tao tao, jie sun, li-sha wei, ye-qiong li, yu-wei zhou, zhen-ji gan, xue-na zhang, hua-qun chen, min-sheng zhu* intragenic mir199a1 in the dnm2 gene contributes to the pathology of x-linked centronuclear myopathy. j biol chem 2020 in press.
7. sun j, tao t, zhao w, wei ls, she f, wang p, li y, zheng y, chen x, wang w, qiao yn, zhang xn, zhu ms*. cpi-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. j genet genomics 2019;46(3):109-118
8. tao t, sun j, peng yj, li y, wang p, chen x, zhao w, zheng yy, wei ls, wang w, zhou yw, liu j, shi ys， zhu ms* golgi-resident trio regulates membrane trafficking during neurite outgrowth. j biol chem 2019;294(28):10954-10968
9. pei wang, wei zhao, jie sun, tao tao, xin chen, yan-yan zheng, cheng-hai zhang, zhong chen, yun-qian gao, fan she, ye-qiong li, li-sha wei, ping lu, cai-ping chen, ji zhou, da-quan wang, liang chen, xiao-hao shi, linhong deng, ronghua zhuge, hua-qun chen, min-sheng zhu*.inflammatory mediators mediate airway smooth muscle contraction through a gpcr-tmem16a-vdcc axis and contribute to bronchial hyperresponsiveness in asthma. j allergy clin immunol 2018;141(4):1259-1268
10. xu s，cao s, zou b, yue y, gu c, chen x, wang p, dong x, xiang z, li k, zhu ms*, zhao qs*, zhou gh* an alternative novel tool for dna editing without target sequence limitation: the structure-guided nuclease. genome biology 2016; 17:186-195
11. zhang ch, wang p, chen cp, zhao w, chen x, chen c, he wq, qiao yn, tao t, sun j, peng yj, craige sm, lifshitz lm, jr kjf, fogarty ke, zhuge r, zhu ms* the molecular basis underlying the genesis of basal tone in internal anal sphincter. nature communication. 2016；7:11358.
12. gao yq, chen x, wang p, lu l, zhao w, chen c, chen cp, tao t, sun j, zheng yy, du jie, li cj, gan zj, gao x, chen hq and zhu ms*. regulation of dlk1 by the maternally expressed mir-379-544 cluster may underlie callipyge polar overdominance inheritance. pnas. 2015; 112(44):13627-32
13. chen, c.p., chen, x., qiao, y.n., wang, p., he, w. q., zhang, c.h., zhao, w., gao, y.q., chen, c., tao, t., sun, j., wang, y., gao, n., kamm, k.e., stull, j.t., and zhu, m.s * roles in vivo for myosin phosphatase targeting subunit-1 t694 and t852 phosphorylation sites in bladder smooth muscle. j. physiology 2015;593(3):681-700 | |||||
承担科研项目[项目负责人] | |||||
在研项目：
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获奖情况 | |||||
2016年国家科技进步二等奖（第2完成人）暨教育部科技进步特等奖（第2完成人）一项基因工程小鼠等相关疾病模型研发与应用 | |||||
