作者:2018-11-22浏览次数:23997

史冬泉-j9集团

博士研究生导师简介

姓名

史冬泉

研究方向:

膝关节(软骨、半月板、韧带、肌腱)发育与再生

j9集团的联系方式

13951003149shidongquan@nju.edu.cn

学术兼职:

中国骨科医师协会骨关节炎工作组       秘书兼委员

中国骨科医师协会再生医学工作组       委员

中国骨科医师协会青年委员会           委员

中华医学会组织修复与再生委员会       青年委员

吴阶平医学基金会青年骨科医师联盟     副主任委员

 annals of joint                      执行主编

 annals of translational medicine     副主编

 bmc surgery                          副主编

《中华关节外科杂志》                 编委

《实用老年医学》                     编委

个人简介

南京大学博士生导师、国家优秀青年基金获得者、全国青联委员(医药卫生界别副主任委员)、江苏省青联医药卫生界别 主任委员;江苏省五四青年奖章获得者、江苏省医学重点人才;南京大学医学院附属鼓楼医院 主任医师。

临床方向:成人重建外科(关节置换、关节重建成形)和运动医学(关节镜及其康复)。擅长运动医学及关节外科疾病的诊治,同时掌握关节镜下治疗交叉韧带损伤、半月板成形等微创手术,以及初次髋膝关节置换。每年完成关节置换约400例,运动医学相关手术200例。并开展了多项临床随机对照试验。

科研业绩:根据骨性关节炎遗传学特质和软骨损伤修复的基础应用研究方面进行了一系列的研究创新,迄今共发表英文论文110篇,包括 acs nanoangew chem int ed englscience advancesnano researchnat mednat genet等。发表sci论文共被引用1890次,每年平均被引135.0次,h指数23。主持nsfc优秀青年项目1,专项项目1项,面青项目3项,科技部国家重点研发计划子课题1项。获得 2014年教育部自然科学二等奖;2015年中华医学会骨科分会青年基础研究奖一等奖;2018年江苏省科技进步一等奖,2019年江苏省医学科技奖二等奖。




代表性论文[5年通讯作者和第一作者]

 1. mimi wan #*; qi wang# ; rongliang wang; rui wu; yueqi yu; ting li; leyi fang; xingwen wang; yinghua zhang; zhuoyue miao; bo zhao; fenghe wang; chun mao* ; qing jiang; xingquan xu; dongquan shi*;platelet-derived porous nanomotor for thrombus therapy. science advances;2020; 6(22): eaaz9014.


 2. meng wang #, wenqiang yan#, meilin chu, ting li, zhiyong liu, yueqi yu, yangyang huang, tianyu zhu, mimi wan*, chun mao*, dongquan shi*. erythrocyte membrane-wrapped magnetic nanotherapeutic agents for reduction and removal of blood cr(vi).acs appl mater interfaces. 2020;12(25):28014-28023.


 3. xingquan xu#; rongliang wang# ; rui wu; wenjin yan; tianshu shi; qing jiang * ; dongquan shi* ;trehalose reduces bone loss of experimental biliary cirrhosis rats via erk phosphorylation regulation by enhancing autophagosome formation. faseb j. 2020;34(6):8402-8415.


 4. wenqiang yan#, xingquan xu#, qian xu, ziying sun, zhongyang lv, rui wu, wenjin yan, qing jiang*, and dongquan shi*;an injectable hydrogel scaffold with kartogenin-encapsulated nanoparticles for porcine cartilage regeneration – a 12-month follow-up study.the american journal of sports medicine.已接收


 5. wenqiang yan#, xingquan xu#, qian xu, ziying sun, zhongyang lv, rui wu, wenjin yan, qing jiang*, and dongquan shi*; chondral defects cause kissing lesions in a porcine model.cartilage.已接收


 6. mimi wan; tingting xu; bo chi; meng wang; yangyang huang; qi wang; ting li; wenqiang yan; huan chen; ping xu; chun mao* ; bo zhao; jian shen * ; hong xu; dongquan shi * ;a safe and efficient strategy for the rapid elimination of blood lead in vivo based on a capture-fix-separate mechanism, angew chem int ed engl., 2019, 58(31): 10582-10586.


 7. wenxu sun#; heting jiang #; xin wu# ; zhengyu xu; chen yao; juan wang;  meng qin; qing jiang; wei wang * ; dongquan shi*; yi cao*; strong , dual-crosslinked hydrogels for ultrasound-triggered drug delivery. nano reaearch, 2019, 12: 115-119.


 8. dongquan shi; xingquan xu; yanqi ye; kai song; yixiang cheng; jin di; quanyin hu; jianxin li; huangxian ju; qing jiang*; zhen gu*; photo-cross-linked, scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration. acs nano, 2016 ,10(1): 1292-1299.


 9. wenqiang yan#; xingquan xu#; qian xu; ziying sun; qing jiang*; dongquan shi*; platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up.regen biomater, 2020, 7(1):77-90.


 10. wenqiang yan#; xingquan xu#; qian xu; wenjin yan; ziying sun; qing jiang*; dongquan shi*; femoral and tibial torsion measurements based on eos imaging compared to 3d ct reconstruction measurements. ann transl med.,2019 ,7(18) :460.


 11. rongliang wang#; xingquan xu#; yixuan li; jiawei li; chen yao; rui wu; qing jiang*; dongquan shi*; a c-met chemical inhibitor promotes fracture healing through interacting with osteogenic differentiation via the mtorc1 pathway. experimental cell research, 2019, 381(1): 50-56.  


 12. jiawei li# ; guojun chen# ; xingquan xu; peter abdou; qing jiang; dongquan shi* ; zhen gu*; advances of injectable hydrogel-based scaffolds for cartilage regeneration. regen biomater. 2019, 6(3): 129-140.


 13. xingquan xu#; rongliang wang#; ziying sun; rui wu; wenjin yan; qing jiang *; dongquan shi*. trehalose enhances bone fracture healing in a rat sleep deprivation model. ann transl med., 2019, 7(14): 297.


 14. wenqiang yan#; xingquan xu#; qian xu; ziying sun; dongyang chen; zhihong xu; qing jiang *; dongquan shi*; in vivo gait kinematics of the knee after anatomical and non-anatomical single-bundle anterior cruciate ligament reconstruction-a prospective study. ann transl med, 2019, 7(24) : 799.


 15. tao jiang#; yao yao#; xingquan xu; kai song; pin pan; dongyang chen; zhihong xu; jin dai; jianghui qin; dongquan shi*; qing jiang*; prevalence and risk factors of preoperative deep vein thrombosis in patients with end-stage knee osteoarthritis. annals of vascular surgery ,2019 , 64 : 175-180.


 16. chen yao#; zhe zhang#; yao yao; xingquan xu; qing jiang *; dongquan shi*; predictive value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for acute deep vein thrombosis after total joint arthroplasty: a retrospective study. j orthop surg res, 2018, 13(1) : 40.


 17. xingquan xu; chen yao; rui wu; wenjin yan; yao yao; kai song; qing jiang*; dongquan shi*; prevalence of patellofemoral pain and knee pain in the general population of chinese young adults: a community-based questionnaire survey. bmc musculoskelet disord ,2018, 19(1): 165.


 18. chen yao#; bowen zhu#; yubao liu; xingquan xu; xianfeng yang; zhihong xu; jin dai; dongyang chen; huajian teng; dongquan shi*; qing jiang*; association of mmp3 col5a1 and col1a1 gene polymorphisms with acl geometric size in chinese population. international journal of clinical and experimental pathology, 2017, 10(2) : 1991-1997.


 19. xingquan xu; dongquan shi*; yubao liu; yao yao; jin dai; zhihong xu; dongyang chen; huajian teng; qing jiang* ;in vivo repair of full-thickness cartilage defect with human ipsc-derived mesenchymal progenitor cells in a rabbit model. exp ther med,2017,14(1) : 239-245.


 20. chen yao; xingquan xu; sheng zhou; xiaoxiao song; dongquan shi*; qing jiang *; total knee arthroplasty conversion after a failed lateral closing wedge high tibial osteotomy with knee hyperextension and secondary ankle degeneration a case report. medicine (baltimore), 2017, 96(29): e7473.


 21. xingquan xu; dongquan shi*; wenjin yan; yao yao; jin dai; yeshuai shen; zhihong xu; dongyang chen; qing jiang *; lack of association of a single nucleotide polymorphism in smoc1 with developmental dysplasia of the hip: a , case-control study. international journal of clinical and experimental pathology,2016, 9(10): 10734-10739.  


 22. xingquan xu; dongquan shi*; yubao liu; yeshuai shen; zhihong xu; jin dai; dongyang chen; huajian teng; qing jiang *; synovium-derived mesenchymal stem cell sheet enhance autologous osteochondral transplantation in a rabbit model. international journal of clinical and experimental medicine, 2016, 9(6):10322-10332.


 23. dongquan shi; xingquan xu; anyun guo; jin dai; zhihong xu; dongyang chen; qing jiang *; bone cement solidifiliation influence the limb alignment and gap balance during tka. biomed res int, 2015, 2015: 109402.


 24. xingquan xu; dongquan shi*; yeshuai shen; zhihong xu; jin dai; dongyang chen; huajian teng; qing jiang *; full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. arthritis res ther ,2015 ,17(1) : 20.


25. dongquan shi; jin dai; zhihong xu; dongyang chen; qing jiang*, update on basic and clinical aspects of osteoarthritis. ann transl med, 2015, 3(10): 142.

承担科研项目[项目负责人]

1. 国家自然科学基金委员会,专项项目,81941009,代谢相关性小型猪骨质疏松模型的 建立,2020-012022-12,在研,主持

2. 江苏省人事厅,六大人才高峰-高层次人才a类,wsw-079,软骨修复,2019-10202210,在研,主持

3. 国家科学技术部,国家重点研发计划,2018yfc1105900,关节软骨再生性植入材料研 发及功能评价,2018-072020-12,在研,主持

4. 国家自然科学基金委员会,面上项目,81772335,缓释小分子药物bio透明质酸凝胶修 复软骨缺损的研究,2018-012021-12,在研,主持

5. 国家自然科学基金委员会,优秀青年科学基金项目,81622033,运动医学,2017-012019-12,已结题,主持

6. 江苏省人事厅,六大人才高峰-高层次人才c类,wsw-061,缓释小分子有机化合物bio 的多肽水凝胶修复软骨缺损,2016-102019-10,已结题,主持

7. 国家自然科学基金委员会,面上项目,81572129,紫外聚合缓释kartogenin plga纳米 颗粒/水凝胶复合支架修复软骨缺损,2016-012019-12,已结题,主持

8. 江苏省卫生健康委员会,科教强卫工程江医学重点人才,缓释小分子药物kartogenin 治疗软骨缺损性疾病,2016-012020-12,在研,主持

9. 江苏省科技厅,重点研发计划社会发展项目,be2016609,缓释小分子药物kortogenin 治疗软骨损伤性疾病,2016-012019-12,已结题,主持

10. 南京市卫生局,杰出青年基金项目,jqx13009,关节腔注射kartogenin修复软骨缺损 ,2013-012016-12,已结题,主持

11. 江苏省人事厅,六大人才高峰-高层次人才d类,wsw-006,软骨再生医学研究,2012-1 02015-10,已结题,主持

12. 国家自然科学基金委员会,青年科学基金项目,81101338aspori基因在发育性髋关 节发育不良发病作用,2012-012014-12,已结题,主持

13. 南京市卫生局,青年科技人才启动项目,第三层次,2011-012015-12,已结 题,主持

14. 中央高校专项基金,南大中央高校苗圃项目,aspori基因在发育性髋关节发育不良发病作用,2008-012012-12,已结题,主持



获奖情况

1. 关节软骨损伤修复研究 江苏医学科技奖二等奖 江苏省医学会 2019

2. 骨关节炎的基础与临床研究 江苏省科技进步奖一等奖 江苏省人民政府 2018

3.coa骨科基础青年研究一等奖 中华医学会 2016

4.骨关节炎的基础与临床研究 自然科学奖二等奖 中华人民共和国教育部 2014

5.骨性关节炎的基础与临床研究 南京市科技进步奖二等奖 南京市人民政府 2013

6.骨性关节炎的基础与临床研究 江苏医学科技奖等奖江苏省医学会 2010

7.骨关节疾患易感基因的多态性研究 江苏省科技进步奖等奖江苏省人民政府 2009

8.骨关节疾患易感基因的多态性研究 南京市科技进步奖一等奖 南京市人民政府 2009

9.2016年第十一届“江苏青年五四奖章”获得者;

10.2016年“南京市青年五四奖章”获得者

11. 2010 oarsi travel award

12. 2014 oarsi travel award




网站地图