陈迪-j9集团

姓名

陈迪

研究方向：

衰老生物学

j9集团的联系方式

chendi@nju.edu.cn

学术兼职：

中国老年学学会衰老与抗衰老科学委员会委员

中国动物学会发育生物学专业委员会委员

frontiers in genetics期刊编委

molecules and cells期刊编委

frontiers in aging期刊编委

个人简介

2004年毕业于美国密苏里大学哥伦比亚分校，获哲学博士学位。2005-2012年间在美国巴克衰老研究所从事博士后和研究员工作。2013年至今在南京大学任副教授。长期从事以秀丽隐杆线虫（c. elegans）为模式的发育和衰老生物学研究。主要研究方向包括:（1）insulin/igf-1和tor信号通路组织特异性调控衰老的系统生物学研究；（2）饮食限制（dietary restriction）延缓衰老的分子机理；（3）rna代谢调控衰老及其相关疾病的分子机制。

代表性论文[近5年通讯作者和第一作者]

1. di wu^#, waijiao cai^#, xuan zhang, jianfeng lan, lina zou, samuel j. chen, zixing wu, di chen*, inhibition of par-1 delays aging via activating ampk in c. elegans. aging, 2020, 12(24): 25700-25717. (^#, co-first authors)

2. jianfeng lan^#, jarod a. rollins^#, xiao zang^#, di wu^#, lina zou, zi wang, chang ye, zixing wu, pankaj kapahi*, aric n. rogers*, di chen*, translational regulation of non-autonomous mitochondrial stress response promotes longevity. cell reports, 2019, 28(4): 1050-1062.e6. (^#, co-first authors)

3. lina zou, di wu, xiao zang, zi wang, zixing wu, di chen*, construction of a germline-specific rnai tool in c. elegans. scientific reports, 2019, 9(1): 2354.

4. lei gao, rujun zhang, jianfeng lan, ruonan ning, di wu, di chen*, weimin zhao*, -dihydroagarofuran-type sesquiterpenes from the seeds of celastrus monospermus and their lifespan-extending effects on the nematode caenorhabditis elegans. journal of natural products, 2016, 79(12): 3039-3046.

5. lei hou^#, dan wang^#, di chen^#, yi liu, yue zhang, hao cheng, chi xu, na sun, joseph mcdermott, william b. mair, jing-dong j. han, a systems approach to reverse engineer lifespan extension by dietary restriction. cell metabolism, 2016, 23(3): 529-540. (^#, co-first authors)

6. jianfeng lan, xuan zhang, di chen*, molecular mechanisms of dietary restriction in aging - insights from caenorhabditis elegans research, science china life sciences, 2015, 58(4): 352-358.

7. di chen*, jiuli zhang, justin minnerly, tiffany kaul, donald l. riddle, kailiang jia*, daf-31 encodes the catalytic subunit of n alpha-acetyl transferase that regulates caenorhabditis elegans development, metabolism and adult lifespan, plos genetics, 2014, 10(10): e1004699.

8. di chen*, patrick wai-lun li, benjamin a. goldstein, waijiao cai, emma lynn thomas, fen chen, alan e. hubbard, simon melov, pankaj kapahi*, germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in c. elegans, cell reports, 2013, 5(6): 1600-1610.

承担科研项目[项目负责人]

在研项目：

1. 2022-2025，细胞色素c调控秀丽隐杆线虫衰老的分子机制研究，国家自然科学基金委面上项目，32171156，58万元。

2. 2021-2026，果蝇和线虫发育代谢资源库的系统构建与分析，科技部国家重点研发计划，子课题，2021yfa0805802，120.86万元。

3. 2020-2023，秀丽线虫神经系统通过mrna可变剪接调控衰老的分子机制研究，国家自然科学基金委面上项目，31971092，58万元。

获奖情况