南京大学医学院-j9集团

胡凯博士
主任医师/教授
电话:13951606283邮箱:kai_hu@nju.edu.cn;hukai70@163.com 地址:江苏省南京市鼓楼区中山路321号研究方向:

角膜病、白内障、斜视

  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

胡凯,主任医师、教授,博士、美国哈佛大学医学院眼科博士后,博士后导师、博士生导师;南京大学医学院附属鼓楼医院眼科行政副主任。临床与科研(基础研究)并举,均具有较丰富的经验;精通英语,能紧跟国际最新医学前沿及趋势。

1994年开始从事眼科临床,精通眼科各种常见病及疑难病症的诊治,手术相对较全面(能较熟练开展常见眼科大、中型手术)。擅长白内障、斜视、视网膜玻璃体疾病(玻璃体切割术)、眼表及角膜疾病、青光眼、泪囊疾病、上睑下垂及眼部整形美容等的手术操作。尤其擅长各种白内障摘除术,斜弱视矫正,玻璃体视网膜手术,眼表角膜干细胞及羊膜移植、复杂眼表重建术。亦擅长应用角膜共聚焦显微镜对各类复杂眼表疾病进行诊治。

通过博士及在美博士后(哈佛大学附属schepens眼科研究所)的研究训练,深入了解国际最新的眼科科研动态,熟练掌握目前常用的细胞、分子生物学实验,免疫学实验以及动物实验操作技术,特别精通激光共聚焦显微成像技术、实时动态小鼠活体双光子显微成像、小鼠活体表面荧光显微成像技术。熟悉各种转基因及基因敲出小鼠的基因鉴定及实验操作。熟悉科学研究中的数据采集、分析、统计以及对英文科学论文的撰写。

中华医学会江苏省眼科学分会委员;

中华医学会南京市眼科学分会委员;

江苏省眼科医师协会基础研究与临床转化学组副组长;

美国眼科学与视觉科学研究协会会员;

国家自然科学基金评审专家;

教育部学位中心评审专家;

南京市紫金山英才高层次人才;

眼科权威期刊iovs等多本sci期刊审稿人。



*为通讯作者

shen w, wang c, jiang j, he y, liang q, hu k*. targeted delivery of herpes simplex virus glycoprotein d to cd169  macrophages using ganglioside liposomes alleviates herpes simplex keratitis in mice. j control release. published online november 23, 2023. doi:10.1016/j.jconrel.2023.11.026 (通讯作者,if=10.8001

zhou n, zheng d, you q, chen t, jiang j, shen w, zhang d, liu j, chen d, hu k*. therapeutic potential of biochanin a in herpes simplex keratitis. pharmaceuticals (basel),2023 sep 1;16(9):1240,. (通讯作者,if=4.6003)

guo r, jiang j, zhang y, liang q, liu j, hu k*. the effects of chalazion and the excision surgery on the ocular surface. heliyon,2023 sep 9;9(9):e19971. (通讯作者,if=4.0004)

liang q, guo r, tsao jr, he y, wang c, jiang j, zhang d, chen t, yue t, hu k*. salidroside alleviates oxidative stress in dry eye disease by activating autophagy through ampk-sirt1 pathway, int immunopharmacol, 2023, 121:110397. (通讯作者,if=5.6002)

guo r, liang q, he y, wang c, jiang j, chen t, zhang d, hu k*. mesenchymal stromal cells-derived extracellular vesicles regulate dendritic cell functions in dry eye disease, cells, 2023, 12: 33. (通讯作者,if=6.0002)

guo r, jiang j, zhang y, liang q, chen t, hu k*. evaluation of corneal dendritic cell density and subbasal nerve density in contact lens wearers using ivcm: a systematic review and meta-analysis,front med (lausanne), 2023, 10:1149803. (通讯作者,if=3.9003)

yun he, chenchen wang, qi liang, rongjie guo, jiaxuan jiang, wenhao shen, kai hu*. pkhb1 peptide induces antiviral effects through induction of immunogenic cell death in herpes simplex keratitis, frontiers in pharmacology. 2022, 13: 1048978. (通讯作者,if=5.6002)

chenchen wang, qi liang, dong sun, yun he, jiaxuan jiang, rongjie guo, tejsu malla, pedram hamrah, xun liu*, zhenping huang*, kai hu*. nectin-1 and non-muscle myosin heavy chain-ⅱb: major mediators of herpes simplex virus-1 entry into corneal nerves,frontiers in microbiology. 2022, 13:830699. (通讯作者,if=5.2002)

wenting cheng, lei zhou, kai hu, dehua kong, wei huang, chuanjun xu, hao li, jinlong li. enzyme-initiated assembly of an extracellular-like two-dimensional nanonetwork as a method to detect procancerous activity, acs sens. 2021, 6(5):1815-1822. (共同第一作者,if=8.9001)

wenting cheng, jiehua ma, dehua kong, zhaoli zhang, adeel khan, changhua yi, kai hu*, yongxiang yi*, jinlong li*. one step electrochemical detection for matrix metalloproteinase 2 based on anodic stripping of silver nanoparticles mediated by host-guest interactions, sensors and actuators b:chemical, 2021, 330:129379. (共同通讯作者,if=8.4001)

arsia jamali, kai hu, victor g. sendra, tomas blanco, maria j. lopez, gustavo ortiz, yureeda qazi, lixin zheng, aslihan turhan, deshea l. harris, pedram hamrah*. characterization of resident corneal plasmacytoid dendritic cells and their pivotal role in herpes simplex keratitis,cell reports , 2020, 32: 108099. (共同第一作者,if=8.8001)

jinlong li, kai hu, yongchen zhang, zhaoli zhang, yongfeng yang. a highly sensitive electrochemical sensor based on dna y-junction for detection of estrogen receptor using target protein protection strategy,analytica chimica acta, 2019, 1086:110-115. (共同第一作者,if=6.2001)

jinlong li, kai hu, zhaoli zhang, xiaoyan teng, xia zhang. click dna cycling in combination with gold nanoparticles loaded with quadruplex dna motifs enable sensitive electrochemical quantitation of the tuberculosis-associated biomarker cfp-10 in sputum m,icrochimica acta, 2019, 186(9):662. (共同第一作者,if=5.7002)

jinlong li*, jiehua ma, yongchen zhang, zhaoli zhang, kai hu*. highly sensitive electrochemical analysis of telomerase activity based on magnetic bead separation and exonuclease iii-aided target recycling amplification, bioelectrochemistry. 2019, 130:107341. (共同通讯作者,if=5.0002)

kai hu, jinlong li, xianwen yuan. microrna-411 plays a protective role in diabetic retinopathy through targeted regulating robo4, european review for medical and pharmacological sciences. 2019, 23: 9171-9179. (第一作者,if=3.3003)

jinlong li, kai hu, yongchen zhang, zhaoli zhang, hao li. highly sensitive detection of smoothened based on the drug binding and rolling cycle amplification, analytical and bioanalytical chemistry. 2019, 41122: 5721-5727. (共同第一作者,if=4.3002)

tejsu malla, jing jiang, kai hu*. clinical outcome of combined conjunctival autograft transplantation and amniotic membrane transplantation in pterygium surgery, international journal of ophthalmology. 2018, 11(03) :395-400. (通讯作者,if=1.4004)

ru tang, yujia zhai, lili dong, tejsu malla, kai hu*. immunization with dendritic cell-based dna vaccine prsc-nldc145.gd-il21 protects mice against herpes simplex virus keratitis, immunotherapy. 2018, 10(03) :189-200. (通讯作者,if=2.8004)



1.国家自然科学基金委员会,面上项目,81870695,激发巨噬细胞的抗复发性hsk新型dna疫苗研制及免疫机制研究,2019-2022,61万,结题,主持。

2.江苏省自然科学基金委员会,bk20201114,介导单纯疱疹病毒侵入眼角膜神经的细胞受体及侵入机制研究,2020-2023,10万,结题,主持。

3.南京鼓楼医院临床专项,2022-lcyj-ms-36,间充质干细胞滴眼液治疗干眼病的临床研究,50万,在研,主持。

4.南京市卫生健康委员会,一般性课题,ykk21095,间充质干细胞悬液滴眼治疗干眼病及其机制研究,2022-2025,3万,在研,主持。

5.南京市卫生健康委员会,重点项目,zkx20022,nectin-1和nmhc-iib在hsv-1眼部感染致潜伏中的作用研究2020-2023,10万,结题,主持。

6.江苏省卫计委医学科研课题,z2018034,新型dna疫苗防治复发性hsk及其机制研究,2019-2020,5万元,结题,主持。

7.中央高校基本科研业务费专项资金资助课题,021414380367,激发巨噬细胞的抗复发性hsk新型dna疫苗研制及免疫机制研究,2018-012019-1210万,结题,主持。

8.南京市医学科技发展课题,ykk16107,dna疫苗prsc-gd•gc-il-21的研制及眼表滴种治疗复发性hsk的研究,2017-2019,8万元,结题,主持。

9.江苏省自然科学基金,bk20141346,新型靶向dc的dna纳米疫苗治疗复发性hsk的实验研究,2014-2017,10万元,结题,主持。

10.南京市科技发展计划,201402001,眼表滴种靶向dc的纳米prsc-nldc145•gd-il-21 dna疫苗治疗复发性hsk的研究,2014-2017,10万元,结题,主持。

11.美国nih r01课题,1r01ey022695-01a1,the role of plasmacytoid dendritic cells in corneal immunity;2012-2018,结题,参与。

唯一发明人已获授权国家发明专利2项(201510362141.2201510362541.3),已获国家实用新型专利2项(2022 2 2480709.9202321577247.0)。有国家发明专利5项和国家实用新型专利1项已进入实质审查阶段或受理。

2021年南京市紫金山英才高层次人才。

网站地图