南京大学医学院-j9集团

马正良，南京大学医学院附属鼓楼医院麻醉医学中心主任、教授、博士生导师，享受国务院政府特殊津贴。现任中华医学会麻醉学分会常务委员、中国研究型医院学会麻醉专业委员会主委、中华医学会麻醉学分会门诊、pacu及日间手术学组组长、江苏省医学会麻醉学分会前任主任委员、江苏省医师协会麻醉学医师分会前任会长。《临床麻醉学杂志》副主编、《国际麻醉学与复苏杂志》、《中华麻醉学杂志》等多家杂志常务编委及编委。主持国家自然科学基金5项及多项省部级以上课题。已发表统计源期刊论文300余篇，sci收录80余篇。江苏省医学领军人才,江苏省医学重点学科主任。

中国研究型医院学会麻醉学专业委员会主任委员

中华医学会麻醉学分会常务委员

中华医学会麻醉学分会门诊、pacu及日间手术学组组长

江苏省医师协会麻醉学医师分会第三届会长

江苏省医学会麻醉学分会第九届主任委员

2019年以来发表论文

1.huang y, hao j, yang x, xu l, liu y, sun y, gu x, zhang w, ma z. pretreatment of the ros inhibitor phenyl-n-tert-butylnitrone alleviates sleep deprivation induced hyperalgesia by suppressing microglia activation and nlrp3 inflammasome activity in the spinal dorsal cord. neurochem res. 2022 sep 14. doi:10.1007/s11064-022-03751-5. epub ahead of print. pmid: 36104611.

2.jiao y, zhang x, liu m, sun y, ma z, gu x, gu w, zhu w. systemic immune inflammation index within the first postoperative hour as a predictor of severe postoperative complications in upper abdominal surgery: a retrospective single-center study. bmc gastroenterol. 2022 aug 27;22(1):403. doi:10.1186/s12876-022-02482-9. pmid: 36030214; pmcid: pmc9419130.

3.jiang l, hao j, yang xl, zhu jx, wang y, huang yl, sun ye, mao yt, ni k, gu xp, ma zl. basolateral amygdala reactive microglia may contribute to synaptic impairment and depressive-like behavior in mice with bone cancer pain. neurochem res. 2022 aug 24. doi: 10.1007/s11064-022-03731-9. epub ahead of print. pmid:36002639.

4.liu q, xu r, xu x, huang y, ma z. characteristics and significance of tlymphocyte subsets in peripheral blood of osteosarcoma mice. transl cancer res.2022 jun;11(6):1503-1509. doi: 10.21037/tcr-22-264. pmid: 35836540; pmcid:pmc9273662.

5.xie h, wei j, ma z, ge w. predictive factors for acute postoperative pain after open radical gastrectomy for gastric cancer. front public health. 2022 jun 1;10:907222. doi: 10.3389/fpubh.2022.907222. pmid: 35719680; pmcid: pmc9200059.

6.han x, liu yj, liu bw, ma zl, xia tj, gu xp. trem2 and cd163 ameliorate microglia-mediated inflammatory environment in the aging brain. j mol neurosci. 2022 may;72(5):1075-1084. doi: 10.1007/s12031-022-01965-4. epub 2022 mar 19. pmid: 35306602.

7.ni k, zhu j, xu x, liu y, yang s, huang y, xu r, jiang l, zhang j, zhang w, ma z. hippocampal activated microglia may contribute to blood-brain barrier impairment and cognitive dysfunction in post-traumatic stress disorder-like rats. j mol neurosci. 2022 may;72(5):975-982. doi: 10.1007/s12031-022-01981-4.epub 2022 feb 15. pmid: 35167061; pmcid: pmc8852956.

8.yang s, xu k, xu x, zhu j, jin y, liu q, xu r, gu x, liu y, huang y, ma z. s-ketamine pretreatment alleviates anxiety-like behaviors and mechanical allodynia and blocks the pro-inflammatory response in striatum and periaqueductal gray from a post-traumatic stress disorder model. front behav neurosci. 2022 apr 14;16:848232. doi: 10.3389/fnbeh.2022.848232. pmid: 35493953;pmcid: pmc9047507.

9.dong r, han y, jiang l, liu s, zhang f, peng l, wang z, ma z, xia t, gu x. connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice. j neuroinflammation. 2022 mar 7;19(1):64. doi: 10.1186/s12974-022-02424-y. pmid: 35255943; pmcid: pmc8903726.

10.zhang y, zhou r, hou b, tang s, hao j, gu x, ma z, zhang j. incidence and risk factors for chronic postsurgical pain following video-assisted thoracoscopic surgery: a retrospective study. bmc surg. 2022 mar 2;22(1):76. doi: 10.1186/s12893-022-01522-1. pmid: 35236334; pmcid: pmc8892711.

11.liu t, song j, zhou q, chu s, liu y, zhao x, ma z, xia t, gu x. the role of 5-ht₇r in the memory impairment of mice induced by long-term isoflurane anesthesia. neurobiol learn mem. 2022 feb;188:107584. doi: 10.1016/j.nlm.2022.107584. epub 2022 jan 12. pmid: 35032676.

12.liu y, song f, yang y, yang s, jiang m, zhang w, ma z, gu x. mitochondrial dna methylation drift and postoperative delirium in mice. eur j anaesthesiol. 2022 feb 1;39(2):133-144. doi: 10.1097/eja.0000000000001620. pmid: 34726198.

13.yang y, liu y, zhu j, song s, huang y, zhang w, sun y, hao j, yang x, gao q, ma z, zhang j, gu x. neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction. free radic biol med. 2022 jan;178:134-146. doi: 10.1016/j.freeradbiomed.2021.12.004. epub 2021 dec 4. pmid: 34875338.

14.liu yj, liu tt, jiang lh, liu q, ma zl, xia tj, gu xp. identification of hub genes associated with cognition in the hippocampus of alzheimer's disease. bioengineered. 2021 dec;12(2):9598-9609. doi: 10.1080/21655979.2021.1999549. pmid: 34719328; pmcid: pmc8810106.

15.jiao y, zhang t, zhang c, ji h, tong x, xia r, wang w, ma z, shi x. exosomal mir-30d-5p of neutrophils induces m1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. crit care. 2021 oct 12;25(1):356. doi: 10.1186/s13054-021-03775-3. pmid: 34641966; pmcid:pmc8507252.

16.wu m, gu x, ma z. mitochondrial quality control in cerebral ischemia- reperfusion injury. mol neurobiol. 2021 oct;58(10):5253-5271. doi:10.1007/s12035-021-02494-8. epub 2021 jul 18. pmid: 34275087.

17.peng l, fang x, xu f, liu s, qian y, gong x, zhao x, ma z, xia t, gu x. amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. front aging neurosci. 2021 aug 25;13:686506. doi: 10.3389/fnagi.2021.686506. pmid: 34512303; pmcid:pmc8425557.

18.song js, sun jj, sun ye, liu y, gu xp, ma zl. [risk factors of massive introperative blood loss in posterior spinal fusion for adolescent idiopathic scoliosis]. zhonghua yi xue za zhi. 2021 apr 13;101(14):1002-1008. chinese. doi: 10.3760/cma.j.cn112137-20200924-02710. pmid: 33845538.

19.ni k, zhang w, ni y, mao yt, wang y, gu xp, ma zl. dorsal root ganglia nr2b-mediated epac1-piezo2 signaling pathway contributes to mechanical allodynia of bone cancer pain. oncol lett. 2021 apr;21(4):338. doi: 10.3892/ol.2021.12599.epub 2021 feb 26. pmid: 33692870; pmcid: pmc7933748.

20.cheng x, gu x, xia t, ma z, yang z, feng hl, zhao y, ma w, ju z, gorospe m, yi x, tang h, wang w. hub and hud repress telomerase activity by dissociating hur from terc. nucleic acids res. 2021 mar 18;49(5):2848-2858. doi: 10.1093/nar/gkab062. pmid: 33589924; pmcid: pmc7969021.

21.liu b, chu s, liu t, song j, ma z, gu x, xia t. effects of 5-ht7 receptors on circadian rhythm of mice anesthetized with isoflurane. chronobiol int. 2021 jan;38(1):38-45. doi: 10.1080/07420528.2020.1832111. epub 2020 oct 21. pmid: 33081564.

22.gong x, xu l, fang x, zhao x, du y, wu h, qian y, ma z, xia t, gu x. protective effects of grape seed procyanidin on isoflurane-induced cognitive impairment in mice. pharm biol. 2020 dec;58(1):200-207. doi: 10.1080/13880209.2020.1730913. pmid: 32114864; pmcid: pmc7067175.

23.gu w, sun y, gu w, huang y, bo j, zhou l, ma z, gu x, zhang w. the analgesic effects of pioglitazone in the bone cancer pain rats via regulating the pparγ/pten/mtor signaling pathway in the spinal dorsal horn. biomed pharmacother. 2020 nov;131:110692. doi: 10.1016/j.biopha.2020.110692. epub 2020,sep 14. pmid: 32942156.

24.wang c, xu k, wang y, mao y, huang y, liang y, liu y, hao j, gu x, ma z, sun y. spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood-spinal cord barrier. reg anesth pain med. 2020 oct;45(10):783-791. doi: 10.1136/rapm-2019-101262. epub 2020 aug 12. pmid: 32796132; pmcid: pmc7513263.

25.song j, chu s, fang x, xu f, zhang p, zhao x, ma z, xia t, gu x. time- restricted feeding alters isoflurane-induced memory deficits. transl neurosci.2020 sep 21;11(1):341-355. doi: 10.1515/tnsci-2020-0130. pmid: 33335774; pmcid:pmc7718622.

26.cui sh, zhu hj, ma zl. [risk factors for postoperative intestinal obstruction in patients undergoing robot-assisted laparoscopic radical prostatectomy]. zhonghua yi xue za zhi. 2020 sep 15;100(34):2652-2657. chinese.doi: 10.3760/cma.j.cn112137-20200330-01006. pmid: 32921012.

27.jiang m, liu y, wu h, ma z, gu x. high estrogen level modifies postoperative hyperalgesia via gpr30 and mmp-9 in dorsal root ganglia neurons. neurochem res. 2020 jul;45(7):1661-1673. doi: 10.1007/s11064-020-03032-z. epub 2020 apr 17. pmid: 32303987.

28.liu y, zhou m, zhu x, gu x, ma z, zhang w. risk and protective factors for chronic pain following inguinal hernia repair: a retrospective study. j anesth. 2020 jun;34(3):330-337. doi: 10.1007/s00540-020-02743-5. epub 2020 feb 3. pmid: 32016530.

29.xing f, fang x, gong xd, zhao x, du y, ma zl, gu xp, xia tj. photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance. neural regen res. 2020 jun;15(6):1094-1101. doi: 10.4103/1673-5374.270415. pmid: 31823890; pmcid: pmc7034272.

30.jiang m, sun y, lei y, hu f, xia z, liu y, ma z, gu x. gpr30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up- regulating gaba_a-α4β1δ subunits in periaqueductal gray in female rats. bmc anesthesiol. 2020 apr 22;20(1):93. doi: 10.1186/s12871-020-01017-7. pmid: 32321426; pmcid: pmc7175561.

31.huang y, wang c, tian x, mao y, hou b, sun y, gu x, ma z. pioglitazone attenuates experimental colitis-associated hyperalgesia through improving the intestinal barrier dysfunction. inflammation. 2020 apr;43(2):568-578. doi:10.1007/s10753-019-01138-3. pmid: 31989391; pmcid: pmc7170986.

32.feng d, jia r, ma z, gu x. [risk factors for nausea and vomiting after adolescent idiopathic scoliosis surgery]. nan fang yi ke da xue xue bao. 2020 mar 30;40(3):394-399. chinese. doi: 10.12122/j.issn.1673-4254.2020.03.18. pmid: 32376591; pmcid: pmc7167309.

33.wu h, zhao x, chu s, xu f, song j, ma z, gu x. validation of the chinese version of the amsterdam preoperative anxiety and information scale (apais). health qual life outcomes. 2020 mar 11;18(1):66. doi: 10.1186/s12955-020-01294-3. pmid: 32160883; pmcid: pmc7065348.

34.mao y, wang c, tian x, huang y, zhang y, wu h, yang s, xu k, liu y, zhang w, gu x, ma z. endoplasmic reticulum stress contributes to nociception via neuroinflammation in a murine bone cancer pain model. anesthesiology. 2020 feb;132(2):357-372. doi: 10.1097/aln.0000000000003078. pmid: 31939851.

35.fang x, xia t, xu f, wu h, ma z, zhao x, gu x. isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice. brain res. 2020 jan 15;1727:146511. doi: 10.1016/j.brainres.2019.146511. epub 2019 oct 28. pmid: 31672472.

36.mao y, huang y, zhang y, wang c, wu h, tian x, liu y, hou b, liang y, rong h, gu x, ma z. cannabinoid receptor 2‑selective agonist jwh015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord. mol med rep. 2019dec;20(6):5100-5110. doi: 10.3892/mmr.2019.10772. epub 2019 oct 25. pmid:31661120; pmcid: pmc6854597.

37.song y, li x, gong x, zhao x, ma z, xia t, gu x. green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress. j nutr biochem. 2019 nov;73:108213. doi: 10.1016/j.jnutbio.2019.07.004. epub 2019 aug 1. pmid: 31704346.

38.zhang z, wu h, liu y, gu x, zhang w, ma z. the gcs-sgk1-atp signaling pathway in spinal astrocytes underlied presurgical anxiety-induced postsurgical hyperalgesia. anesth analg. 2019 oct;129(4):1163-1169. doi: 10.1213/ane.0000000000003682. pmid: 30113397.

39.ruan jp, chen l, ma zl. activation of spinal extacellular signal-regulated kinases and c-jun n-terminal kinase signaling pathways contributes to morphine- induced acute and chronic hyperalgesia in mice. j cell biochem. 2019 sep;120(9):15045-15056. doi: 10.1002/jcb.28766. epub 2019 apr 23. pmid:31016764.

40.jiang m, bo j, lei y, hu f, xia z, liu y, lu c, sun y, hou b, ni k, ma z, gu x. anxiety-induced hyperalgesia in female rats is mediated by cholecystokinin 2 receptor in rostral ventromedial medulla and spinal 5-hydroxytryptamine 2b receptor. j pain res. 2019 jul 3;12:2009-2026. doi: 10.2147/jpr.s187715. pmid:31308730; pmcid: pmc6613357.

41.sun r, liu y, hou b, lei y, bo j, zhang w, sun y, zhang y, zhang z, liu z, huo w, mao y, ma z, gu x. perioperative activation of spinal α7 nachr promotes recovery from preoperative stress-induced prolongation of postsurgical pain. brain behav immun. 2019 jul;79:294-308. doi: 10.1016/j.bbi.2019.02.017. epub 2019 feb 21. pmid: 30797046.

42.huo w, liu y, lei y, zhang y, huang y, mao y, wang c, sun y, zhang w, ma z, gu x. imbalanced spinal infiltration of th17/treg cells contributes to bone cancer pain via promoting microglial activation. brain behav immun. 2019 jul;79:139-151. doi: 10.1016/j.bbi.2019.01.024. epub 2019 jan 24. pmid:30685532.

43.liu hy, xia tj, zhu zz, zhao x, qian y, ma zl, gu xp. effect of neuromuscular blockade on transcranial electric motor evoked potentials during surgical correction for idiopathic scoliosis under total intravenous anesthesia. j clin monit comput. 2019 jun;33(3):471-479. doi: 10.1007/s10877-018-0182-8.epub 2018 jul 20. pmid: 30030702.

44.wang zy, gu wj, luo x, ma zl. risk factors of delayed awakening after aortic arch surgery under deep hypothermic circulatory arrest with selective antegrade cerebral perfusion. j thorac dis. 2019 mar;11(3):805-810. doi: 10.21037/jtd.2019.02.01. pmid: 31019768; pmcid: pmc6462705.

45.wang lw, zhu mj, li y, wang st, zhou my, yu yj, ma zl. fkbp51 is associated with early postoperative cognitive dysfunction in elderly patients undergoing hip fracture surgery. medicine (baltimore). 2019 feb;98(5):e14037. doi:1097/md.0000000000014037. pmid: 30702561; pmcid: pmc6380859.

46.qian y, xia t, cui y, chu s, ma z, gu x. the role of camkii in neuropathic pain and fear memory in chronic constriction injury in rats. int j neurosci. 2019 feb;129(2):146-154. doi: 10.1080/00207454.2018.1512986. epub 2018 dec 5. pmid: 30118368.

47.wu h, huang y, tian x, zhang z, zhang y, mao y, wang c, yang s, liu y, zhang w, ma z. preoperative anxiety-induced glucocorticoid signaling reduces gabaergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal pas domain protein 4. mol pain. 2019 jan-dec;15:1744806919850383. doi:10.1177/1744806919850383. pmid: 31041873; pmcid: pmc6537253.

国家自然科学基金（面上项目6项）

1. 国家自然科学基金（82171225）：2022年批准。星形胶质细胞突触吞噬异常诱导的脊髓兴奋/抑制失衡在骨癌痛形成中的作用（55万），2022年01月-2025年12月，主持

2. 国家自然科学基金（81971044）：2019年批准。基于endomt探讨hecw2可变剪接通过抑制dab1信号调控血管-神经通信在睡眠剥夺致术后慢性疼痛中的作用机制（55万），2020年1月至2023年12月，主持

3. 国家自然科学基金（81671087）：2016年批准。脊髓水平外周th17/treg细胞迁移介导小胶质细胞极化在骨癌痛形成中的作用（60万），2017年1月至2020年12月，主持

4. 国家自然科学基金（81471129）：2015年批准。脊髓水平gr-npas4信号通路对gaba能抑制性突触的调节在术前焦虑加重术后疼痛中的作用，2015年-2017年，主持

5. 国家自然科学基金（81171048）：2011年批准。creb-mir212/132-torc1-creb信号通路反馈性调控网络在骨癌痛维持中的作用（55万），2012.1-2015.12，主持

6. 国家自然科学基金（81070892）：2010年批准。脊髓水平kif17-mlin10-nr2b转运通路在骨癌痛发生中的作用（32万），2011.1-2013.12，主持

国家级重点研发计划课题（1项）

1. 国家重点研发计划课题（课题号3-2）：围术期差异化用药及疼痛智能化管理（40万）2018年申报成功，主持

省部级课题10项

1.江苏省卫生厅（xk201140）：江苏省医学重点学科，2012.1-2016.12，主持

2. 江苏省自然科学基金（bk2010105）：脊髓水平nr2b-psd95-nnos信号通路在骨癌痛发生中的作用，2011.1-2013.12，主持

3. 江苏省六大人才高峰课题（2010056）：脊髓水平gsk3β/nr2b/pp1/gsk3β信号环路在瑞芬太尼诱发痛觉过敏中作用的基础及临床研究，2011.1-2013.12，主持

4. 江苏省自然科学基金（bk2009054）：脊髓水平camkⅱ介导的kif17-nr2b转运系统在小鼠骨癌痛形成中的作用，2010.1-2012.12，主持

5. 江苏省六大人才高峰课题（2009044）:大麻素受体cb2-nmda受体nr2b磷酸化通路在癌性疼痛中的作用，2010.1-2012.12，主持

6. 江苏省卫生厅重点课题（h200943）：nr2b-gsk3β信号通路在瑞芬太尼诱发痛觉过敏中基础与临床研究，2010.1-2013.12，主持

7. 江苏省教育厅开放课题（wk200501）：谷氨酸转运蛋白在慢性坐骨神经痛脊髓水平调控作用的实验研究，2006.1-2009.12，主持

8. 江苏省卫生厅兴卫工程（rc2007012）癌痛发生机制及其防治的基础及临床研究，2006.01-2011.12，主持

9. 卫生部重点人才（wkj2006-2-8）骨癌痛脊髓水平痛信号的调制及临床干预的研究，200601-200912,主持

10. 江苏省卫生厅医学科技发展基金（z200306）兴奋性毒性在hie中的作用及γ-羟丁酸钠的干预，200301-200612，主持

市厅级课题5项

1. 南京市卫生局科研课题（ykk10062）：脊髓水平cox-2在骨癌痛模型中的作用及干预的研究，2012.1-2014.12，主持

2. 南京市卫生局重点课题（zkx08028）：cdk5-nr2b磷酸化通路在瑞芬太尼诱发的痛觉过敏中的作用，2009.1-2010.12，主持

3. 南京市科技局课题（200801076）：老年冠心病人围术期处理策略优化，2008.1-2009.12，主持

4. 南京市卫生局重点项目（zkm05046）脊髓nr2b重塑在慢性疼痛发生中的作用及鞘内用药的基础和临床干预研究，200501-200812,主持

5. 南京市科技局社会发展项目（200504019-4）脊髓背角星形胶质细胞和nmda受体在癌痛发生中可塑性改变的基础及临床研究，200501-200612,主持

1.2021年江苏省医学引进新技术：优化的麻醉管理策略在肺动脉高压产妇剖宫产中的应用（一等）

2.2018年江苏省教育教学与研究成果奖：围术期优化镇痛政策的基础及临床研究（三等）

3.2017年江苏省医学新技术引进奖：优化的综合血液保护技术在复杂脊柱矫形手术中的应用（一等）

4.2015年江苏省科学技术奖：脊髓水平nr2b转运和调控在急慢性疼痛中的作用及干预，基础与临床研究（二等）

5.2012年江苏省医学新技术引进奖：右旋美托咪定为主的舒适化医疗技术在临床麻醉中的应用（一等）

6.2011年南京市科学技术进步奖：脊髓水平痛信号调控在急、慢性疼痛中的作用及干预的基础和临床研究（二等）

7.2011年江苏省医学技术奖：脊髓水平痛信号调控在急、慢性疼痛中的作用及干预的基础和临床研究（二等）

8.2010年江苏省医学新技术引进奖：nmd受体拮抗剂防治雷米芬太尼痛觉过敏技术在麻醉中的作用（一等）

9.2004年南京市医学新技术引进奖：小剂量甾体抗炎硬膜外给药法在术后阵痛的作用（一等）

10.2004年南京市医学新技术引进奖：改良肺内分流率测定技术临床的应用（三等）

11.2004年南京市医学新技术引进奖：旁气流监测呼吸监测功能在围术期的运用（一等）

12.2004年南京市医学新技术引进奖：蛛网膜下系持续颅内压监测与调控（二等）

13.2004年江苏省医学新技术引进奖：围术期心、脑、肺保护及其机制研究（二等）

14.2003年徐州市科学技术进步奖：泼尼松龙硬膜外给药用于脊柱手术后镇痛的临床与基础研究（267三等）

15.2003年徐州市科学技术进步奖：吸入麻醉药对重要脏器功能的影响及其机制的研究（002一等）

16.1999年江苏医学科技进步奖：七氟醚对肝脏影响的研究（99-24-1二等）