南京大学医学院-j9集团

医学博士、主任医师、教授、博导，现为南京医科大学附属脑科医院副院长、精神大科主任、心境障碍科主任、江苏省抑郁症专病中心主任、南京神经精神病学研究所副所长。入选江苏省科教强卫工程领军人才、优秀医学重点人才，获江苏省“333工程”第二层次人才、江苏省六大高峰人才、江苏省医学拔尖人才、江苏省有突出贡献中青年专家等称号。带领的临床团队荣获江苏省“科教强卫工程”省市共建医学创新团队、全国人文爱心科室、五一巾帼标兵岗等称号。发表论文200余篇，获国家发明授权4项、软件著作权2项。相关研究成果获华夏医学科技奖三等奖（2021）、江苏省科技进步奖二等奖（2020、2014）、江苏省医学科技进步奖二等奖（2015）、南京市科学技术进步奖二等奖（2015）、三等奖（2013）、江苏省医学新技术引进奖一等奖（2013、2016、2021）和南京市医学新技术引进奖特等奖（2020）、一等奖（2016）等。

中华医学会精神医学分会委员兼抑郁障碍研究协作组副组长

中国医师协会精神科委员兼精准医疗专委会副主委

江苏省医师协会精神科医师分会会长

江苏省医学会精神医学分会第九届主委

江苏省精神科专业医疗质控中心主任

[1]yan r, geng jt, huang yh, zou hw, wang xm, xia y, zhao s, chen zl, zhou h, chen y et al: aberrant functional connectivity in insular subregions in somatic depression: a resting-state fmri study. bmc psychiatry 2022, 22(1):146.

[2]wang x, qin j, zhu r, zhang s, tian s, sun y, wang q, zhao p, tang h, wang l et al: predicting treatment selections for individuals with major depressive disorder according to functional connectivity subgroups. brain connect 2022. https://doi.org/10.1089/brain.2021.0153

[3]shao j, zhang y, xue l, wang x, wang h, zhu r, yao z, lu q: shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study. neuropsychopharmacology : official publication of the american college of neuropsychopharmacology 2022. https://doi.org/10.1038/s41386-022-01290-9

[4]zhou h, zou h, dai z, zhao s, hua l, xia y, han y, yan r, tang h, huang y et al: interoception dysfunction contributes to the negative emotional bias in major depressive disorder. frontiers in psychiatry 2022, 13:874859.

[5]wang q, tian s, zhao p, cao q, lu q, yao z: association between antidepressant efficacy and interactions of three core depression-related brain networks in major depressive disorder. frontiers in psychiatry 2022, 13:862507.

[6]chen z, zhao s, tian s, yan r, wang h, wang x, zhu r, xia y, yao z, lu q: diurnal mood variation symptoms in major depressive disorder associated with evening chronotype: evidence from a neuroimaging study. journal of affective disorders 2022, 298(pt a):151-159.

[7]dai z, pei c, zhang s, tian s, chen z, zhou h, lu q, yao z: attenuated alpha-gamma coupling in emotional dual pathways with right-amygdala predicting ineffective antidepressant response. cns neurosci ther 2022, 28(3):401-410.

[8]yan r, huang y, shi j, zou h, wang x, xia y, zhao s, zhou h, chen y, li x et al: alterations of regional spontaneous neuronal activity and corresponding brain circuits related to non-suicidal self-injury in young adults with major depressive disorder. journal of affective disorders 2022, 305:8-18.

[9]dai z, shao j, zhou h, chen z, zhang s, wang h, jiang h, yao z, lu q: disrupted fronto-parietal network and default-mode network gamma interactions distinguishing suicidal ideation and suicide attempt in depression. progress in neuro-psychopharmacology & biological psychiatry 2022, 113:110475.

[10]zhang s, litvak v, tian s, dai z, tang h, wang x, yao z, lu q: spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder. eur arch psychiatry clin neurosci 2022:1-11.

[11]sun y, wang x, tian s, chen z, wang h, xue l, yan r, yao z, lu q: an investigation into the association between dopamine receptor d1 multilocus genetic variation, multiparametric magnetic resonance imaging, and antidepressant treatment. j magn reson imaging 2022, 56(1):282-290.

[12]wang h, zhu r, tian s, zhang s, dai z, shao j, xue l, yao z, lu q: dynamic connectivity alterations in anterior cingulate cortex associated with suicide attempts in bipolar disorders with a current major depressive episode. journal of psychiatric research 2022, 149:307-314.

[13]dai z, shen x, tian s, yan r, wang h, wang x, yao z, lu q. gradually evaluating of suicidal risk in depression by semi-supervised cluster analysis on resting-state fmri. brain imaging behav. 2021;15(4):2149-2158.

[14]zhao s, chen z, wang x, yao z, lu q. increased prevalence of subclinical hypothyroidism in female hospitalized patients with depression. endocrine. 2021;72(2):479-485.

[15]wang x, qin j, zhu r, zhang s, tian s, sun y, wang q, zhao p, tang h, wang l, si t, yao z, lu q. predicting treatment selections for individuals with major depressive disorder according to functional connectivity subgroups. brain connect. 2021 dec 16. doi: 10.1089/brain.2021.0153.

[16] xue l, pei c, wang x, wang h, tian s, yao z, lu q. predicting neuroimaging biomarkers for antidepressant selection in early treatment of depression. j magn reson imaging. 2021 aug;54(2):551-559.

[17]zhang y, shao j, wang x, chen z, liu h, pei c, zhang s, yao z, lu q. functional impairment-based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects. hum brain mapp. 2021 aug 15;42(12):4035-4047.

[18]dai z, zhang s, wang x, wang h, zhou h, tian s, chen z, lu q, yao z. sub-second transient activated patterns to sad expressions in major depressive disorders discovered via hidden markov model. j neurosci res. 2021 dec;99(12):3250-3260. doi: 10.1002/jnr.24942. 

[19]zhao s, wang x, chen z, zhou h, han y, tang h, yan r, yao z, lu q. sex differences in the association between symptom profiles and cognitive functioning in patients with depressive disorder. j affect disord. 2021;287:1-7.

[20] chen z, tao s, zhu r, tian s, sun y, wang h, yan r, shao j, zhang y, zhang j, yao z, lu q. aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: bridging rora gene polymorphism with diurnal mood variation in major depressive disorder. j psychiatr res. 2021;132:123-130.

[21]tang h, xiong t, shi j, chen y, liu x, zhang s, wang h, lu q, yao z. global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes. bmc psychiatry. 2021,26;21(1):117.

[22]xue l, pei c, wang x, wang h, tian s, yao z, lu q. predicting neuroimaging biomarkers for antidepressant selection in early treatment of depression. j magn reson imaging. 2021;54(2): 551-559.

[23]sun y, tao s, tian s, shao j, mo z, wang x, wang h, zhao p, chen z, yao z, lu q. serotonin 2a receptor polymorphism rs3803189 mediated by dynamics of default mode network: a potential biomarker for antidepressant early response. j affect disord. 2021,15;283:130-138.

[24]tian s, zhu r, chattun mr, wang h, chen z, zhang s, shao j, wang x, yao z, lu q. temporal dynamics alterations of spontaneous neuronal activity in anterior cingulate cortex predict suicidal risk in bipolar ii patients. brain imaging behav.  2021, 15(5):2481-2491. 

[25] qiao j, tao s, wang x, shi j, chen y, tian s, yao z, lu q. brain functional abnormalities in the amygdala subregions is associated with anxious depression. j affect disord. 2020;276:653-659.

[26] han yl, dai zp, ridwan mc, lin ph, zhou hl, wang hf, yao zj, lu q. connectivity of the frontal cortical oscillatory dynamics underlying inhibitory control during a go/no-go task as a predictive biomarker in major depression. front psychiatry. 2020;11:707. 

[27]jiang h, zhu r, tian s, wang h, chen z, wang x, shao j, qin j, shi j, liu h, chen y, yao z, lu q. structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode. neuropsychopharmacology. 2020; 45(10):1735-1742.

[28]wang h, zhu r, dai z, tian s, shao j, wang x, sun y, chen z, li x, yao z, lu q. aberrant functional connectivity and graph properties in bipolar ii disorder with suicide attempts.  j affect disord. 2020; 275:202-209.

[29]yang y,  chattun mr,  yan r,  zhao k,  chen y,  zhu r,  shi j,  wang x,  lu q,  yao z. atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters. brain imaging and behavior. 2020,14(6):2542-2552. if 3.418.

[30] zhao p,  yan r,  wang x,  geng j,  chattun mr,  wang q,  yao z,  lu q. reduced resting state neural activity in the right orbital part of middle frontal gyrus in anxious depression. frontiers in psychiatry 2020; 10: 994. if 3.161.

[31] zhou h,  hua l,  jiang h,  dai z,  han y,  lin p,  wang h,  lu q,  yao z. autonomic nervous system is related to inhibitory and control function through functional inter-region connectivities of ofc in major depression. neuropsychiatr dis treat 2020; 16: 235-247.

[32] tian s,  zhang s,  mo z,  chattun mr,  wang q,  wang l,  zhu r,  shao j,  wang x,  yao z,  si t,  lu q. antidepressants normalize brain flexibility associated with multi-dimensional symptoms in major depressive patients. progress in neuropsychopharmacology& biological psychiatry, 2020; 100: 109866.

[33]tian s,  sun y,  shao j,  zhang s,  mo z,  liu x,  wang q,  wang l,  zhao p,  chattun mr,  yao z,  si t,  lu q. predicting escitalopram monotherapy response in depression: the role of anterior cingulate cortex. hum brain mapp. 2020;41:1249–1260. doi: 10.1002/hbm.24872.

[34] zhou h, dai z, hua l, jiang h, tian s,han y, lin p, wang h, lu q and yao z. (2020) decreased task-related hrv is associated with inhibitory dysfunction through functional interregion connectivity of pfc in major depressive disorder. 2020, frontiers psychiatry 10:989. if 3.161.

[35] chattun mr, zhang s, chen y, wang q, amdanee n, tian s, lu q, yao z. caudothalamic dysfunction in drug-free suicidally depressed patients: an meg study.  european archives of psychiatry and clinical neuroscience. 2020, 270(2):217-227.

[36] rongxin zhu, shui tian, huan wang, haiteng jiang, xinyi wang, junneng shao, qiang wang, rui yan, shiwan tao, haiyan liu, zhijian yao, qing lu. discriminating suicide attempters and predicting suicide risk using altered frontolimbic resting-state functional connectivity in patients with bipolar ii disorder. frontiers in psychiatry,2020,11:597770.

[37] wang q, shi j, zhao p, cao q, yao z. neuroleptic malignant syndrome with abnormally elevated cardiac troponin i: a case report. j int med res. 2020 nov;48(11):300060520968344.

[38] pei c, sun y, zhu j, wang x, zhang y, zhang s, yao z, lu q. ensemble learning for early-response prediction of antidepressant treatment in major depressive disorder. j magn reson imaging. 2020;52(1):161-171.

[39]jiang h, hua l, dai z, tian s, yao z, lu q, popov t. spectral fingerprints of facial affect processing bias in major depression disorder. soc cogn affect neurosci. 2019. 257:74-82.

[40] jiang h,  dai z,  lu q,  yao z. magnetoencephalography resting-state spectral fingerprints distinguish bipolar depression and unipolar depression. bipolar disorders. 2020, 22(6):612-620.

[41]bi k , luo gp, tian s, zhang sq, liu xx , wang q, lu q, yao zj.an enriched granger causal model allowing variable static anatomical constraints [j].neuroimage: clinical, 2019, 21:101592.

[42] shao j, dai z, zhu r, wang x, tao s, bi k, tian s, wang h, sun y, yao z, lu q. early identification of bipolar from unipolar depression before manic episode: evidence from dynamic rfmri. bipolar disord. 2019, 21(8):774-784. epub ahead of print. if 4.936

[43] jiang ht, tian s, bi k, lu q, yao zj. hyperactive frontolimbic and frontocentral resting-state gamma connectivity in major depressive disorder. j affect disord. 2019,2;257:74-82. if 4.084.

[44] yan r, tao s, liu h, chen y, shi j, yang y, zhu r, yao z and lu q. abnormal alterations of regional spontaneous neuronal activity in inferior frontal orbital gyrus and corresponding brain circuit alterations: a resting-state fmri study in somatic depression. frontiers in psychiatry,2019, 10:267.

[45]wang x, qin j, zhu j, bi k, zhang sq, yan r, zhao p, yao zj, qing lu. rehabilitative compensatory mechanism of hierarchical subnetworks in major depressive disorder: a longitudinal study across multi-sites[j]. european psychiatry, 2019.58: 54-62.

[46]wang q, tian s, tang h, liu xx, yan r, hua ll, shi jb, chen y, zhu rx, lu q, yao zj. identification of major depressive disorder and prediction of treatment response using functional connectivity between the prefrontal cortices and subgenual anterior cingulate: a real-world study[j]. journal of affective disorder, 2019, 252:365-372.

[47] tian s, mohammad ridwanchattun, zhang sq, bi k, tang h, yan r, wang q, yao zj, lu q. dynamic community structure in major depressive disorder: a restingstate meg study. progress in neuropsychopharmacology& biological psychiatry. 2019,92,39-47.

[48] geng jt, yan r, shi jb, chen y, mo zq, shao jn, wang xy, yao zj, lu q. altered regional homogeneity in patients with somatic depression: a resting-state fmri study.journal of affective disorders, 2019, 246:498-505. if 4.084.

[49] zhang q, zhang p, yan r, xu x, mao c, liu x, li f, ma j, ye l, yao z, wu j. a single-blinded trial using resting-state functional magnetic resonance imaging of brain activity in patients with type 2 diabetes and painful neuropathy. diabetes therapy, 2019, 10(1):135-147.

[50]shi jb, geng jt, yan r, liu xx, chen y, zhu rx, wang xy, shao jn, bi q, yao zj, lu q. differentiation of transformed bipolar disorder from unipolar depression by resting-state functional connectivity within reward circuit. frontiers in psychology, 9:2586.

[51] liu hy, zhao zk, shi jb, chen cy, yao zj, lu q. topological properties of brain structural networks represent early predictive characteristics for the occurrence of bipolar disorder in patients with major depressive disorder: a 7-year prospective longitudinal study. frontiers in psychiatry, 2018,9:704.

[52]bi k , mohammad rc, liu xx , wang q, tian s, zhang sq, lu q, yao zj. abnormal early dynamic individual patterns of functional networks in low gamma band for depression recognition[j]. journal of affective disorders, 2018.238：366-374.

[53] tao s, chattun mr, yan r, geng j, zhu r, shao j, yao z, lu q. tph-2 gene polymorphism in major depressive disorder patients with early-wakening symptom. frontiers in neuroscience. 2018, 12:827.

[54] chen jh, chen y, gao qq, chen gt, dai yt, yao zj, lu q. impaired prefrontal-amygdala pathway, self-reported emotion and erection in psychogenic erectile dysfunction patients with normal nocturnal erection[j]. frontiers in human neuroscience, 2018, 12: 157.

（1）国家自然科学基金委员会, 面上项目, 81871066, 抑郁症昼夜节律变化的视交叉上核gamma波脑网络的调控机制, 2019-01-01 至 2022-12-31, 56万元, 在研, 主持

（2）国家科技部, 国家重点研发计划重大慢性非传染性疾病防控研究重点专项, 2018yfc1314601, 抑郁症复发的预警体系建立和综合干预策略研究项目--抑郁症复发的临床表型、风险因子研究, 2018-09 至 2021-06, 86万元, 结题, 主持

（3）江苏省卫健委, 江苏省卫健委科研重点项目, k2019011, 基于多维度特征的重性抑郁发作患者自杀风险防控策略研究, 2020-01 至 2022-12, 20万元, 在研, 主持

（4）江苏省科技厅, 江苏省社会发展--临床前沿技术, be2018609, 基于多源数据的抑郁症防控关键技术与策略研究, 2018-07 至 2021-06, 400万元, 结题, 主持

（5）江苏省卫生和计划生育委员会, 江苏省“科教强卫工程”省市共建创新团队, cxtdc2016004, 基于影像遗传学信息的抑郁症关键技术研究, 2016-01 至 2020-12, 300万元, 结题, 主持

华夏医学科技奖三等奖（2021）、江苏省科技进步奖二等奖（2020、2014）、江苏省医学科技进步奖二等奖（2015）、南京市科学技术进步奖二等奖（2015）、三等奖（2013）、江苏省医学新技术引进奖一等奖（2013、2016、2021）和南京市医学新技术引进奖特等奖（2020）、一等奖（2016）等。