南京大学医学院-j9集团

医学博士，解放军东部战区总医院神经外科副主任，全军神经外科研究所神经介入中心主任，主任医师，南京大学教授，南京大学、南京医科大学、南方医科大学、南京中医药大学博士生导师，博士后导师，第二军医大学、东南大学、江苏大学及南京工业大学硕士研究生导师。1999年开始从事神经介入的临床与基础工作，在脑血管疾病介入诊断、治疗方面积累了丰富的经验，对复杂的颅内动脉瘤、脑动静脉畸形及硬膜动静脉瘘等的栓塞治疗有深入的研究。每年完成各类脑血管疾病的介入治疗近600余例，以第一或通讯作者共发表文章90余篇（其中sci 30篇）。江苏省“科教强卫”重点人才，江苏省六大人才高峰培养对象，作为第一负责人主持国家自然基金等外源性课题8项，2014年获江苏省新技术引进奖一等奖。2016年获全军医疗成果三等奖。

先后任中国医师协会神经介入专业委员会委员，中华医学会神经外科分会神经介入学组委员，中国医师协会神经外科分会神经介入专业委员会委员，中国脑防委外科专业委员会常务委员，中国卒中学会神经介入分会委员，江苏省卒中学会常务理事兼神经介入专业委员会副主任委员，江苏省医学会神经外分会常委兼神经介入学组组长，江苏省医学会介入医学分会委员兼神经介入组组长，江苏省医学会卒中分会委员，南京医学会神经外科分会副主任委员等。

1. xiangsheng zhang, qi wu, yue lu, jieru wan, haibin dai, xiaoming zhou, shengyin lv, xuemei chen, xin zhang, chunhua hang, jian wang. cerebroprotection by salvianolic acid b after experimental subarachnoid hemorrhage occurs via nrf2- and sirt1-dependent pathways.free radical biology and medicine，124（2018）:504-516. https://doi.org/10.1016/j.freeradbiomed.2018.06.035

2. 吕盛银，张鑫。动脉瘤性蛛网膜下腔出血认知功能障碍的评估及研究进展。医学研究生学报，2018，31（8）：859-863。

3. jiang shao, qi wu, sheng-yin lv, xiao-ming zhou, xiang-sheng zhang, li-li wen, jin xue, xin zhang. allicin attenuates early brain injuruy after experimental subarachnoid hemorrhage in rats. journal of clinical neuroscience.https://doi.org/10.1016/j.jocn.2019.01.024.

4. 袁斌，张鑫，吴琪，文立利，陈姝娟，邓金龙。动脉瘤性蛛网膜下腔出血后静脉早显合并过度灌注一例并文献复习。中华神经外科杂志，2019，35（3）315-317。

5. 袁斌，张鑫，吴琪，文立利，尤宗琦，徐伟东，陈姝娟，邓金龙。大脑中动脉粥样硬化性狭窄支架置入后高灌注脑出血的研究进展。中国脑血管病杂志，2019，16（3）：158-163。

6. xiangsheng zhang, yue lu, qi wu, haibin dai, wei li, shengyin lv, xiaoming zhou, xin zhang, chunhua hang, and jian wan. astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the toll-like receptor 4 signaling pathway. the faseb journal, 27 dec 2018, https://doi.org/10.1096/fj.201800642rr.

7. 尤宗琦，吴琪，周晓明，张翔圣，袁斌，徐伟东，唐祥龙，张鑫。虾青素纳米载药颗粒靶向神经元细胞的可行性研究。中华实验外科杂志，2019，8（36）：1387-1390。

8. xiaoming zhou, qi wu, yue lu, xiangsheng zhang, shengyin lv, jiang shao, yuan zhou, jigang chen, lijun hou, chengguang huang, and xin zhang. a crosstalk between soluble pdgf-bb and pdgfrb promotes astrocytic activation and synaptic recovery in the hippocampus after subarachnoid hemorrhage. the faseb journal,2019,33, 0892-6638/19/0033-0001.

9. zong-qi you, qi wu, xiao-ming zhou, xiang-sheng zhang, bin yuan, li-li wen, wei-dong xu, sheng cui, xiang-long tang and xin zhang. receptor-mddiater delivery of astaxanthin-loaded nanoparticles to neurons: an enhanced potential for subarachnoid hemorrhage treatment. front neurosci, 2019 sep 18;13:989.

10. xin-yu lu and  xin zhang. onyx™ embolization for an angiographically progressive traumatic pseudoaneurysm of the middle meningeal artery: a case report and literature review. experimental and therapeutic medicine, 2019(17):  4144-4148.

11. bin yuan, xiao-ming zhou, zong-qi you, wei-dong xu, jie-mei fan, shu-juan chen, yan-ling han, qi wu and xin zhang. inhibition of aim2 inflammasome activation alleviates gsdmd-induced pyroptosis in early brain injury after subarachnoid haemorrhage. cell death and disease ,(2020) 11:76

12. wei-dong xu, han wang, qi wu, li-li wen, zong-qi you, bin yuan, shu-juanchen, han-dong wang, xin zhang. morphology parameters for rupture in middle cerebral artery mirror aneurysms. j neurointervent surg 2020;0:1–5. doi:10.1136/neurintsurg-2019-015620

13. bin yuan, xiao-ming zhou, jie-mei fan, shu-juan chen, zong-qi you, wei-dong xu, li-li wen, jin-long deng, qi wu, xin zhang. safety and efficacy of different therapeutic strategies in the endovascular treatment of anterior cerebral artery aneurysms with different features: a single centre experience. clinical neurology and neurosurgery 193 (2020) 105786.

14. zhizhong yan, zhonghua shi, yuhai wang, chunlei zhang, jiaming cao, chunlong ding, mirui qu, yunbao xia, jin cai, xin zhang, and handong wang. efficacy and safety of low-dose tirofiban for acute intracranial atherosclerotic stenosis related occlusion with residual stenosis after endovascular treatment. journal of stroke and cerebrovascular diseases, 2020 apr;29(4):104619.

15. 唐晓宇，文立利，吴琪，张安，周龙江，张鑫。小尺寸自膨式支架在颅内小血管动脉瘤治疗中的应用。《中国脑血管病杂志》２０２０，１７（9）538-542。

16. zhao shi, chongchang miao, u. joseph schoepf, rock h. savage, danielle m. dargis, chengwei pan, xue chai, xiu li li, shuang xia, xin zhang, yan gu, yonggang zhang, bin hu, wenda xu, changsheng zhou, song luo, hao wang, li mao, kongming liang， lili wen, longjiang zhou, yizhou yu, guang ming lu，long jiang zhang。a clinically applicable deep-learning model for detecting intracranial aneurysm in computed tomography angiography images。nature communications | (2020) 11:6090 (共同第一作者)

17. 姚磊,吴琪,文立利,周晓明,何伟臻,张闰秋,邓金龙,陈姝娟,张鑫。enterprise支架重建技术治疗椎动脉夹层动脉瘤的效果分析。《中国脑血管病杂志》,2021,18( 1 ):18-24.

18. yao lei,qi wu, bin yuan, lili,wen,renxin yi, xiaoming zhou,weizhen he, runqiu zhang, shujuan chen, xin zhang. correlation between vascular geometry changes and long-term outcomes after enterprise stent deployment for intracranial aneurysms located on small ateries. world neurosurg, 2021 sep;153:e96-e104.

19. wen ll, zhou xm, lv sy, shao j, wang hd, zhang x .outcomes of high-grade aneurysmal subarachnoid hemorrhage patients treated with coiling and ventricular intracranial pressure monitoring. world journal of clinical cases 2021 volume 9 issue 19。

20. wei cai, qi wu, zhi-zhong yan, wei-zhen he, xiao-ming zhou, long-jiang zhou, jian-yong zhang, xin zhang. neuroprotective effect of ultrasound triggered astaxanthin release nanoparticles on early brain injury after subarachnoid hemorrhage. front chem,2021 oct 21;9:775274.

21. lili wen, longjiang zhou, qi wu. early microcirculatory hemodynamic changes are correlated with functional outcomes at discharge in patients with aneurysmal sah. front neurol,2022 jan 20;12:793411.

22. xiaoyu tang, longjiang zhou, lili wen. morphological and hemodynamic characteristics associated with the rupture of multiple intracranial aneurysms.front neurol,2022 jan 20;12:811281.

23. weizhen he, xiaoming zhou, et al. acetyl coa synthase 2 potentiates atg5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage. j mol histol,2022 apr;53(2):511-521.

24. lili wen, longjiang zhou, qi wu, xiaoming zhou and xin zhang. feasibility of fdct early brain parenchymal blood volume maps in predicting short-term prognosis in patients with aneurysmal subarachnoid hemorrhage. front. neurol. 13:888369.

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